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desvenlafaxine will increase the amount or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment necessary with desvenlafaxine doses 7 consecutive times immediate